• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The object of the invention is a method of closing a container with a liquid, said container comprising a body (10) with an opening at at least one end and comprising at least one plug (14-1) of closure, intended to close said opening after filling, said filling defining a free filling surface S, the filling having left a head space in said container, characterized in that it consists in carrying out the following different steps: d) introduction of at least one rod (18-1) parallel to an inner wall of the body (10) of said container, e) Mechanical insertion of said plug (14-1) into the body (10), along the at least one insertion rod (18-1), generating at least one channel C, the air of the headspace being discharged between said plug and said rod, removing said at least one rod (18-1) leaving said plug in place at the insertion level of the previous step L'inventio It also covers the associated device and the industrial production line.
    公开号:FR3041334A1
    申请号:FR1558862
    申请日:2015-09-21
    公开日:2017-03-24
    发明作者:Jean Pascal Zambaux；Bernard Pauchdet
    申请人:DISPOSABLE-LAB；
    IPC主号:
    专利说明:

    METHOD FOR FILLING A CONTAINER COMPRISING AT LEAST ONE PLUG, IN PARTICULAR A CARPULE, INSERTION MEANS AND ASSOCIATED SHUTTER LINE
    The present invention relates to a method for sealing a container comprising at least one stopper, in particular a carpule. The invention also covers the insertion means associated with its various variants. The invention finally covers a closure line for containers, in an industrial manner.
    For the rest of the description, the choice chosen to exemplify in a nonlimiting manner is an application to a carpule for the medical field.
    The description would apply equally well to containers whose one end is closed and which must be filled and closed at the second end by a cap penetrating into said container, generating a minimum of air, such as a syringe body.
    Indeed, in the medical field, intradermal injection syringe devices are widely used but many patients may present a phobia of the needles and the action generated by the needle. This is how children can be sensitive but adults also especially when it is a repetitive treatment such as treatments for allergies or for daily doses in the case of long-term treatments. Also, to remedy this, there are needleless injection means, including means disseminated under the Zenéo trademark filed the company CrossJect.
    Such means operate by propelling the liquid contained in a carpule by means of placing under very high localized pressure so as to penetrate the liquid contained in said cartridge through the dermis. An injection head ensures the diffusion of the liquid in many streams of very small diameters.
    There is therefore no longer a needle and it is sufficient to position an applicator on the dermis and to trigger by simple pressure the implementation of the means of putting under very high pressure, which causes the injection of the liquid by projection to very high speed through the dermis. It is understood that, if the liquid must be put under very high pressure, almost instantaneously, it is necessary that the cartridge containing said liquid is free from air or at least that the volume of air is as small as possible in order to absorb as little as possible the pressure wave exerted by the means for putting under very high pressure.
    The closer the transmission of almost instantaneous pressure to the liquid, the more effective and quality penetration will be.
    But the current filling can be greatly improved.
    A carpule consists of a container in the form of a tube, usually glass, thick to resist pressure, with a peripheral lip ends for its maintenance and positioning.
    This container, in the form of a tube, is closed at a first proximal end by a first plug, integrally introduced into the tube, at one end. This plug is provided with sealing means with the wall of said tube. This plug, thus positioned, nevertheless remains capable of moving under the strong pressure that will be exerted during its use in order to release the liquid contained in said tube by this proximal end which is equipped with a diffusion head. This diffusion head aims to distribute the diffused volume in very many very small diameter jets.
    During manufacture, the tube-shaped container, closed by this proximal plug, and intended to carry a diffusion head, must then be filled with the liquid to be dispensed by its other distal end. This distal end is then closed by a distal plug, while waiting for its use.
    The distal plug must also enter the tube integrally firstly because the dimensions of the tube-shaped container are standard and the volume of liquid to be dispensed may be variable and secondly, because the second plug will receive and transmit the very strong pressure generated. This second plug will then behave as a piston to transmit this very high pressure under the action of the means for putting under very high pressure.
    In addition, the carpules are used as cartridges in other fields such as the dental field, for example for the administration of anesthesia products. In this case, this administration necessarily uses a syringe into which the so-called cartridge cartridge is introduced directly into this professional environment. Here again, it is necessary to limit the volume of air, to transmit the pressure exerted on the piston directly to the anesthetic fluid, without a volume of buffer air that would absorb part of the force or at least with a volume of air minimum which would render the depreciation capacity negligible.
    Anesthetic fluids most often have a high viscosity requiring strong pressure from the practitioner to ensure good penetration of the anesthetic into the gum.
    The carpules are also used in the veterinary field or the problem of filling the cartridges and other carpules with a minimum of air also arises. A known solution for filling and closing a carpule with a cap which consists in plugging the carpule by its proximal end, filling the carpule, putting the carpule under vacuum, introducing the distal plug when the carpule is under vacuum and then breaking the empty. The distal plug then moves into the tube constituting the carpule.
    This method has a first problem related to the control of the displacement in translation of the first plug.
    The reproducibility is delicate and especially in the case of an error or an incomplete displacement, there is no possibility to "complete" the movement or to start again or to re-aspire. The content of the carpule is lost, which can be very detrimental when the product is expensive. Generally, the distal plug consists of a plug body having at least two annular lips generally three, arranged one above the other along the longitudinal axis of the cartridge and spaced from each other.
    These lips constitute the sealing of the distal plug and constitute as many barriers to the leakage of the fluid composition contained in the cartridge as the penetration of foreign bodies and microorganisms provided that said lips remain free of any trace of liquid composition at right of these lips.
    The mechanical filling is therefore very delicate and remains a problem to be solved.
    In addition, such carpules are produced in large numbers and it is necessary that the process and the device are adapted to be put into service on industrial production lines with high capacity and high rate. The present invention also provides a closure line adapted for particular application to needleless injection cartridges.
    Reproducibility is absolutely essential in order to confer on all the carpules produced the same parameters and to lead to a use with homogeneous performances of the injection means using said carpules.
    It is also necessary to provide a method and introduction means which are of a non-crippling cost.
    The method and the insertion means according to the present invention are now described in detail according to a particular embodiment, not limiting, this description being established for a carpule application without being limiting to this type of container. This description is based on the set of appended drawings, drawings on which the various figures show, by way of illustration only:
    Figure 1 is a perspective view of a carpule with its first top cap, distal before placement, and its second proximal lower cap in place,
    Figure 2 is a schematic view of the insertion means of the first plug,
    FIGS. 3A to 3F: a view of a block diagram of the sealing method according to the present invention, with the different steps,
    Figure 4: a view of a variant of the process with an additional step,
    5A to 5B: a view of alternative embodiments of the rod of the insertion means, FIGS. 6A to 6H: a production line with the associated steps for closing with the aid of the device according to the present invention.
    In Figure 1, there is shown a cartridge of known type, serving as a non-limiting illustration to the following description. This cylindrical carpule comprises a tubular body, with two ends: an upper end 10-1 and a lower end 10-2.
    This carpule has two upper crowns 12-1 and lower 12-2. These rings 12 are positioned at the outer periphery of the upper or distal and lower or proximal ends of the body 10.
    Each crown is positioned in a plane perpendicular to the longitudinal axis XX 'of the carpule, passing through the longitudinal axis of the body 10.
    The body and the crowns form a monolithic assembly and are generally made of glass, said glass being a thick glass so as to withstand high pressure.
    The concerned carpule is designed to receive two plugs, made of a material of the elastomer type: a first upper plug 14-1 and a second lower plug 14-2, liberator.
    The second lower plug 14-2 is introduced in a first operation in order to close the body 10 at its second end 10-2, this second stopper being a stopper liberating the product under the action of the very high pressure.
    The body 10 and the second lower cap 14-2 in place thus form a container for receiving a liquid composition. The filling is carried out in a known manner, for example by means of a dosing nose, not shown.
    The first upper plug 14-1 must in turn be introduced into the body 10 in order to seal the upper end of the tubular body.
    The sealing method according to the present invention proposes the following steps to achieve closure with the first plug 14-1 by moving said plug in the immediate vicinity of the free filling surface S which is the free surface of the liquid composition.
    The volume between this free filling surface S and the plug is called "headspace" and must be minimized to solve the problems mentioned in the preamble.
    The process consists of:
    Introducing at least a portion of insertion means 18 parallel to the interior of the body 10 of the container, in this case the carpule,
    Mechanically insert the first plug 14-1 in the body 10, to an insertion level of said plug in the body such that the air of the head space is discharged between the plug and the insertion means 18, and
    Remove at least the portion of the insertion means 18 leaving the first plug in place at the insertion level of the previous step.
    The insertion means 18 according to the present invention comprise in particular a rod 18-1, of circular section in the simplified embodiment shown.
    This rod 18-1 can take different irregular sections, as shown in FIGS. 5A and 5B, in particular an elliptical section and an elliptical section with diametrical bosses.
    These sections further facilitate the evacuation of air by generating channels Ç outlet of upper section or generating, for the same section of channels, a higher mechanical strength of the rod, as explained further.
    When the first plug 14-1 is mechanically introduced, at least one generatrix of said plug, since it is cylindrical, bears on the rod 18-1 constituting part of the insertion means 18. This therefore generates at least one channel for evacuating the air as the plug is translated into the body 10, along the axis XX '.
    The stem 18-1 is then removed from the body 10 of the carpule. This is made possible because the contact area between the rod 18-1 and the first top plug 14-1 generates lower frictional forces than those generated between the periphery of the plug and the inner wall of the body of the carpule.
    The first plug 14-1, made of elastomeric material, resumes its initial shape and instantly compensates for the removal of the rod 18-1.
    Preferably, according to a characteristic of the method, the rod 18-1 is positioned with its lower end in the immediate vicinity of the free filling surface S, avoiding contact with the liquid composition 16. Indeed, such contact would have the effect of polluting the space between the inner wall of the body 10 and the first top cap 14-1, during the withdrawal of said rod 18-1.
    According to another characteristic of the present method, it is possible to add an additional step of inclining the body 10 during its insertion. This inclination is carried out along a generatrix, opposite the generatrix receiving the rod, so that the head space is concentrated on the side of the rod
    Means 18 for introducing the first upper plug 14-1 are now described in detail with reference to FIGS. 2 and 3, according to a preferred embodiment.
    These figures also illustrate the complete device according to the invention, allowing the implementation of the method which is described.
    In Figure 2, the introduction means 18 comprise a rod 18-1 integral with a guide head 18-2 which comprises a passage 18-3 provided with a funnel-shaped inlet 18-4. The guide head 18-2 is cylindrical and peripherally chamfered, intended to bear and reference on the upper end 10-1, and more particularly on the crown 12-1 upper.
    The introduction means 18 further include a cap holder 18-5 for receiving and holding the first upper plug 14-1 in a through housing 18-6 in the center of said plug holder, and coaxially with the axis. XX '.
    The cap holder 18-5 is of a profile conjugate with that of the head 18-2 for guiding so as to cap said head and to ensure a coaxial positioning before introduction.
    A mechanical actuator 18-7 is schematically shown as a piston 18-8.
    The implementation of the insertion means 18 which have just been described is now explained with reference to FIGS. 3 which represent the corresponding block diagram.
    In FIG. 3A, there is shown a carpule with a body 10 and two upper crowns 12-1 and 12-2 lower. These rings 12 are positioned at the outer periphery of the upper ends 10-1 and 10-2 of the body 10.
    The second lower plug 14-2 is in place and closes the lower end 10-2.
    The body 10 has received a volume of a liquid composition 16 whose free filling surface S is at a height (c).
    The guide head 18-2 is positioned in abutment and in reference on the upper end 10-1 and on the ring 12-1.
    In this position, the stem 18-1 comes immediately above the free filling surface S, without contact, see FIG. 3B.
    The head 18-2 guide can also be styled on the crown for better positioning.
    In FIG. 3C, the cap holder 18-5 is coaxially attached to the guide head 18-2.
    The passage 18-3 provided with a funnel-shaped inlet 18-4 is perfectly centered on the axis XX '.
    The first upper plug 14-1 is held in the through-housing 18-6 formed in the center of said plug holder 18-5, and is also positioned coaxially with respect to the axis XX '.
    The piston 18-8 is above the cap holder 18-5, waiting and also coaxial with the axis XX '.
    In FIG. 3D, the piston 18-8 is moved in translation according to the indication of the arrow of this figure.
    The piston 18-8 bears on the upper face of the first top plug 14-1 and forces it into the funnel-shaped inlet 18-4, which again centers said plug and causes a certain radial compression of said plug .
    During the translation, the peripheral edge of the plug comes into contact with the rod 18-1, which generates at least one channel Ç which allows the evacuation of the air, as and when the insertion by translation of the first capl4-l upper in the body 10. The cap leaves the cap holder 18-5 which then no longer function.
    In FIG. 3E, it can be seen that the first plug 14-1 goes down and that the air escapes.
    The piston pushed the plug 14-1 to a referenced position (b) leaving a very small headspace.
    The plug 14-1 is generally made of elastomeric material and comprises in sealing at least two lips, in this case three lips 11, 12 and 13, It being closest to the lower end, plus the upper part of the body of the plug. The dimensions are adapted according to the needs, the nature of the materials, the inside of the body 10 can previously undergo a suitable surface treatment.
    The liquid composition 16 sees its filling surface S in a position ç and the first lip 11 is in a position (a).
    It is found that the position of the rod must be located, at the lowest, immediately above the free surface S filling the liquid contained in the body of the container, at least above the position (c).
    This prevents the liquid composition from coming into contact with the end of the rod 18-1 and pollutes it.
    The first lip 11 thus provides a first effective barrier without any trace of liquid composition 16 immersed between said lip and the inner wall of the body 10.
    In this Figure 3F, the piston 18-8 is removed and the plug 14-1 remains in place. It is noted that the other lips 12 and 13 also take up their sealing position because of the elastomeric nature of said material as soon as the rod is removed.
    Similarly, the friction on this elastomeric material remains totally negligible and it causes no movement of the plug during removal of the rod.
    Regarding the rod, so as not to damage in any way the inner face of the tubular body, to facilitate the introduction of the first plug, it is possible to provide a surface treatment of said wall.
    An advantageous solution also consists in producing said rod from a material known by the name of PEEK which is polyetherketone, having mechanical properties largely sufficient for the application of the present invention and whose coefficient of friction is very limited.
    Then simply remove the cap door 18-5 which is free of cap and the head 18-2 guide.
    These two withdrawals can be made simultaneously.
    According to an improvement of the present invention, provision is made to be able to slightly tilt the body 10 as shown in FIG. 4 so as to concentrate the volume of air at the end of the thrust on the stopper at a place situated at the right of the end of the rod 14-1. Thus the head space is concentrated in one point.
    This step is optional because, depending on the products, the wettability of the liquid composition is sufficient to come immediately below the underside of the first plug 14-1. The head volume is then reduced to the peripheral ring located under the first lip 11, which is extremely limited and totally acceptable especially for the intended application of administration from a cartridge under very high pressure.
    This is all the more acceptable for pre-filled single-dose syringes with manual pressure. As regards the method and the sealing means allowing its implementation, it can be seen that this process can be industrialized and an illustration of an industrial production line is now described with reference to FIGS.
    The benchmarks in the industrial production line remain identical.
    In this case, the line includes 72 simultaneous poses.
    FIG. 6A diagrammatically shows a positioning press which comprises a frame 20 with guide columns 22, a bottom plate 24 intended to receive a container-carrying tray 26, in this case cartridges if the the description is continued for this particular application to carpules. This bottom plate 24 comprises means 28 for moving the tray 26 cartridge holder in horizontal translation.
    There is also provided an upper plate 30 which is movable in translation on the guide columns 22. This upper plate 30 carries a set of pistons 18-1 with the same geometric distribution as that of the carpules.
    A third intermediate plate 32 is also movable in translation on the guide columns 22, parallel to the upper plate 30. This intermediate plate 32 comprises a plate 34 with as many door plugs 18-2 and rods 18-1 as carpules with the same geometric distribution. The rods 18-1 are off-center with respect to the plugs 14-1 so as to be positioned substantially in line with the periphery of each plug.
    The frame 20 may also, although not shown, have a "dirty" area and a "clean" or sterile area to keep the carpules in the clean area.
    Since the frame 20 is in the configuration of FIG. 6A, the bottom plate 24 carries a cartridge holder plate 26, said cartridges being filled with a liquid composition 16 and having previously received a second closure plug at the lower end. 10-2. These steps are not part of the invention because they are well known in themselves.
    The intermediate plate 32 is positioned above the bottom plate 24 to allow removal of the cartridge holder plate 26. The rods 18-1 are then centered with respect to the axis XX 'of the carpules and the plugs 18-2 in the stopper are off-center. In FIG. 6B, the first step is the descent of the intermediate plate 32 which ensures that the rods 18-1 are placed centrally and thus coaxial with the axis XX 'of the cartridges. The step of FIG. 6C consists in causing a displacement in horizontal translation until the rods come along an internal generatrix of the body 10 of each carpule. The plugs 14-1 are then centered relative to the carpules and the heads 18-2 also guide. The rods 18-1 are, they, eccentric, positioned along an inner generatrix of the body 10.
    This step is optional but is nevertheless the best embodiment because it avoids the accidental support of at least one rod 18-1 on the upper annular portion 12-1 of a carpule, which could cause the rupture and for the less the deformation of the rod concerned. In step 6D, the upper plate 30 is moved downwardly, causing the pistons 18-8 to descend simultaneously.
    The plugs 14-1 are thus extracted from the cap-carrying tray 34 and penetrate through each respective guide head 18-2, into the funnel passage 18-4 and then into the passage 18-3.
    The upper platen with its pistons is then brought back into the initial position by an upward translation, as shown in FIG. 6E, to allow removal of the platen 34 corks.
    In FIG. 6F, the upper plate 30 is lowered again but lower to push the plugs 14-1 out of the guide head, into the body 10, and to reduce the head space. Each cap is moved in translation of the guide head which held it in the body of the corresponding carpule.
    Each stopper being pushed in translation along the inner wall of the body 10 of each cartridge and along the associated stem 18-1, the air or the neutral gas in the case of closure under a neutral atmosphere, can escape through the channels thus formed, as explained above in the description.
    The descent level is adjusted according to the filling data to obtain, for each carpule, a filling of the liquid composition at a level (c), a lower end of the plug 14-1 at a level (b) and an end of the stem at a level (a).
    It is understood that it is possible to provide the establishment of several rods for each carpule so as to generate more air or gas evacuation channels and / or to symmetry the shutter operation. This may allow a better balancing of the cap during the descent.
    Figure 6G provides the translational movement of the intermediate plate 32 leaving in place the pistons 18-8 and thus the upper plate 30, in the low position. This avoids any displacement of each plug during the withdrawal of the needles. The risk is low but the maintenance of the caps during the withdrawal of the needles is an additional guarantee.
    The length of the pistons must be planned accordingly.
    Figure 6H shows the return of the plate 30 in the high position.
    The tray of carpules filled and sealed with a headspace, minimized, is ready to be prepared for marketing. The carpules of the tray can be integrated into an applicator, in particular to casings of injection devices without needles.
    According to a variant of the method, the rod 18-1 and the plug 14-1 can be introduced simultaneously.
    The sealing process thus makes it possible to minimize head space, the sealing means are simple and industrial and the production line meets the industrial needs.
    权利要求:
    Claims (15)
    [1" id="c-fr-0001]
    1. A method of sealing a container with a liquid, said container comprising a body (10) with an opening at at least one end and having at least one plug (14-1) shutter, intended to close off said opening after filling, said filling defining a free filling surface S, the filling having left a head space in said container, characterized in that it consists in carrying out the following different steps: a) Introduction of at least one rod (18-1) parallel to an inner wall of the body (10) of said container, b) Mechanical insertion of said plug (14-1) in the body (10), along the at least one rod (18-1) of insertion, generating at least one channel Ç, the air of the headspace being discharged between said plug and said rod, c) Removing said at least one rod (18-1) leaving said plug in place at the insertion of the previous step.
    [2" id="c-fr-0002]
    2. A method of sealing a container with a body having an opening at least one end, according to claim 1, characterized in that the steps a) of introduction of the rod (18-1) and b) d insertion of the plug (14-1) are simultaneous.
    [3" id="c-fr-0003]
    A method for sealing a container with a body having an opening at at least one end, according to claim 1 or 2, characterized in that the insertion rod (18-1) is introduced until its end is immediately above the free surface S filling of the composition (16) liquid, contained in the body (10) of the container.
    [4" id="c-fr-0004]
    4. A method of sealing a container with a body having an opening at least one end, according to any one of the preceding claims, characterized in that, in the case of a plug (14-1) comprising at least one less a lip (11-13), the insertion rod (18-1) is introduced so that its end is positioned to the right of the lip (11) closest to the free surface S of the composition (16) liquid .
    [5" id="c-fr-0005]
    5. A method of sealing a container with a body having an opening at at least one end, according to any one of the preceding claims, characterized in that, in the case of a body (10) cylindrical, the direction introduction of the rod (18-1) is parallel to a generator.
    [6" id="c-fr-0006]
    6. A method of sealing a container with a body having an opening at least one end, according to any one of the preceding claims, characterized in that the body (10) and / or the stem (18-1) and / or the plug (14-1) undergo a pre-surface treatment or are made of a material with a low coefficient of friction, to reduce the coefficient of friction.
    [7" id="c-fr-0007]
    7. A method of sealing a container with a body having an opening at least one end, according to any one of the preceding claims, characterized in that the plug (14-1) is held in place mechanically during the step c / removal of the rod (18-1).
    [8" id="c-fr-0008]
    8. A method of sealing a container with a body having an opening at least one end, according to any one of the preceding claims, characterized in that the body (10) of the container is inclined during the evacuation of air by positioning the container so that the end of the rod (18-1) comes to the top of the head space.
    [9" id="c-fr-0009]
    9. A method of sealing a container with a body having an opening at least one end, according to any one of the preceding claims, characterized in that the body (10) is a cartridge comprising, in addition to the upper end (10-1) closed by the plug (14-1) shutter, another end (10-2) previously closed with a plug (14-2) liberator.
    [10" id="c-fr-0010]
    10. Device for closing a container with a body having an opening at least one end, for carrying out the method according to any one of the preceding claims, characterized in that it comprises a head (18- 2) guiding a plug (14-1) in said filled container, at least one rod (18-1) and a cap holder (18-5) and a mechanical actuator (18-7) comprising at least one minus one piston (18-8).
    [11" id="c-fr-0011]
    11. Device for closing a container with a body having an opening at least one end, according to claim 10, characterized in that the rod (18-1) has a disc-shaped section.
    [12" id="c-fr-0012]
    12. Device for sealing a container with a body having an opening at least one end, according to claim 10, characterized in that the rod (18-1) has an irregular section.
    [13" id="c-fr-0013]
    13. Container production line by implementing the method according to one of claims 1 to 9 and the device according to one of claims 10 to 12, in particular for use in needleless syringes, each container comprising a body (10) with open first and second ends (10-1, 10-2), characterized in that it comprises a placing press comprising: a frame (20) with guide columns (22), a bottom plate (24) intended to receive a tray (26) container holder, with a distribution geometry, a plate (30) upper, movable in translation on the columns (22), provided with a set of pistons (18) -1), with the same distribution geometry as the containers, an intermediate plate (32) also movable in translation on the columns (22) for guiding, parallel to said upper plate (30), provided with a plate (34) door plugs (18-2) with as many plugs (14-1) and rods (18-1) than containers with the same geometric distribution,
    [14" id="c-fr-0014]
    14. Container production line according to claim 13, characterized in that the lower plate (24) comprises means (28) for moving the tray (26) container holder in horizontal translation.
    [15" id="c-fr-0015]
    15. Container production line according to claim 13 or 14, characterized in that the rods (18-1) are off-center relative to the plugs (14-1) so as to be positioned substantially to the right of the periphery of each plug (14-1).
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    同族专利:
    公开号 | 公开日
    EP3144230B1|2019-09-11|
    EP3144230A1|2017-03-22|
    FR3041334B1|2020-02-14|
    US20170081056A1|2017-03-23|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US3737973A|1970-10-20|1973-06-12|Becton Dickinson Co|Method and device for assembling a stopper to a syringe barrel|
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    法律状态:
    2016-09-29| PLFP| Fee payment|Year of fee payment: 2 |
    2017-03-24| PLSC| Search report ready|Effective date: 20170324 |
    2017-09-28| PLFP| Fee payment|Year of fee payment: 3 |
    2018-09-28| PLFP| Fee payment|Year of fee payment: 4 |
    2019-09-26| PLFP| Fee payment|Year of fee payment: 5 |
    2020-09-14| PLFP| Fee payment|Year of fee payment: 6 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1558862A|FR3041334B1|2015-09-21|2015-09-21|PROCESS FOR SEALING A CONTAINER COMPRISING AT LEAST ONE PLUG, IN PARTICULAR A CARPULE, MEANS OF INSERTION AND ASSOCIATED SEALING LINE|
    FR1558862|2015-09-21|FR1558862A| FR3041334B1|2015-09-21|2015-09-21|PROCESS FOR SEALING A CONTAINER COMPRISING AT LEAST ONE PLUG, IN PARTICULAR A CARPULE, MEANS OF INSERTION AND ASSOCIATED SEALING LINE|
    EP16189512.3A| EP3144230B1|2015-09-21|2016-09-19|Method for obturation of a cartridge comprising at least one plug, means of insertion and associated obturation line|
    US15/272,174| US20170081056A1|2015-09-21|2016-09-21|Method of sealing a container comprisingat least one plug, particularly a carpule, insertion means and associated sealing line|
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